불소의 대안 : 나노 메디칼 하이드록시아파타이트 nano<mHAp>

THE ALTERNATIVE ANTICARIES AGENT(충치예방물질의 새로운 대안)

 

HYDROXYAPATITE

• safe 안전합니다.
• biocompatible 생체친화적입니다.
• edible 먹을 수 있습니다.
• enamel-restorative 에나멜(치아표면)을 수복합니다.
• anticariogenic 충치예방효과가 있습니다.
• a crystalline form of calcium phosphate 칼슘포스페이트의 결정구조를 갖습니다.
• as effective as fluoride 불소만큼 효과적입니다.

Safe A key Component of Human Body

Hydroxyapatite is a major component of the human body, comprising 60% of bone, 97% of tooth enamel and 70% of dentin. Saliva is also rich in the components of hydroxyapatite, which it supplies to the teeth to replace mineral dissolved by plaque acids, the first step towards tooth decay.By restoring lost mineral, saliva acts to protect against decay in a natural healing process known as ‘remineralization.’ Sangi’s Medical Hydroxyapatite supports this natural healing function,

Biocompatible Used Widely in Dental & Medical Applications

Because it is extremely biocompatible, hydroxyapatite is used in a wide range of medical and dental applications, such as artificial tooth and bone, tissue repair, and coatings to improve the biocompatibility of orthopedic implants. It is also a protein-binding agent, used in chromatography and bacterial culture. In dental applications, hydroxyapatite is sometimes used as an abrasive,depending on its manufactured properties and particle size. However Sangi’s nanohydroxyapatite is a non-abrasive, enamel-restorative mineral, closely resembling the natural hydroxyapatite of the teeth, and approved in Japan for its anticaries properties.

Edible A Dietary Calcium Phosphate Source

Hydroxyapatite is also a rich source of easily digested calcium phosphate, and is used in dietary supplements, remineralizing chewing gum, and as an additive in foods.

Enamel-Restorative An Alternative to Fluoride for Anticaries Use

The influence of fluoride in reducing dental caries has been clearly demonstrated. Its use in drinking water and oral care products dates back over 70 years. Fluoridation has been called the single most effective public health measure to prevent new tooth decay, and early U.S. studies showed it reduced caries among schoolchildren by as much as 35-60%. However excess fluoride can lead to problems such as dental or skeletal fluorosis, and the amount permitted in oral care products and community water systems is controlled.

In contrast, nano Medical Hydroxyapatite, used as a remineralizing agent in toothpaste in Japan for the last three decades, was shown in field trials leading to its approval as an active anticaries ingredient to cause a similar reduction in new caries among schoolchildren to that seen with fluoridation in the U.S., namely 36-56%.(Fig 1.T.KANI et al Effect to Apatite-containing Dentifricres on Dental Caries in school Children)

　

Fig 1. Average increase in new caries using the test toothpaste once daily for 1 year (Group A) and 3 years (Group B)Fig 2. Remineralization effect of fluoride and nanohydroxyapatite toothpastes, by pH cycling

A recent in situ study conducted among healthy adults in the U.S. found that Sangi’s Medical Hydroxyapatite toothpaste not only inhibited development of caries but was not significantly different from fluoride in its ability to remineralize early caries lesions. (Amaechi et al, Remineralization of Early Caries Lesions by Nanohydroxyapatite Dentifrice). This supported the findings of earlier in vitro studies in Hong Kong which showed no significant difference in remineralizing effect between fluoride- and Medical Hydroxyapatite (‹mHAP ›)-containing toothpastes. (NM King et al, Remineralization by Nanohydroxyapatite-containing Dentifirice)

Moreover, hydroxyapatite has been shown to be safe – even edible – and can be swallowed by children without concern, as it has no known toxic or harmful impact.

Action of Fluoride

Fluoride is an element (F-), supplied in the form of compounds such as sodium fluoride (NaF) or sodium monofluorophosphate (NaMFP). It does not replace mineral itself, but strengthens teeth against decay by promoting the uptake of calcium and phosphate from saliva and other sources into the enamel (remineralization). In doing so, it forms a new substance, fluoridated apatite, on the tooth surface, more resistant to plaque acids than the enamel’s original carbonated hydroxyapatite. Fluoride is also said to impede bacterial metabolism, helping to lower the level of cariogenic bacteria in the mouth.

Action of Medical Hydroxyapatite

In contrast, nano Medical Hydroxyapatite is a crystalline calcium phosphate substance almost identical to the natural hydroxyapatite of our teeth. Supplied in the form of nanoparticles, it directly replaces lost mineral to restore subsurface demineralized areas of tooth enamel (incipient caries) and fill microscopic fissures on the enamel surface. Its nanoparticles also bind protein such as oral bacteria and plaque fragments during brushing, facilitating their removal from the mouth.
Unlike fluoride, nano Medical Hydroxyapatite adds nothing ‘new’ to the enamel, and is less resistant to acid attack than fluoridated apatite, though more resistant than carbonated apatite. But Medical Hydroxyapatite achieves the same degree of remineralization as fluoride, as seen above, and penetrates to the very bottom of demineralized lesions, whereas fluoride tends to create a dense zone of fluoridated apatite at the top.
And by restoring the enamel’s mineral density and surface smoothness, Medical Hydroxyapatite increases resistance to bacterial attachment and therefore plaque development and tooth decay, at the same time enhancing the translucency, gloss and whiteness of the teeth.