아파프로, 나노 메디칼 하이드록시아파타이트

나노 메디칼 하이드록시 아파타이트(nano <mHAP>)란 무엇일까?

MECHANISM OF ACTION

The main substance of our teeth is hydroxyapatite (97 % of enamel and 70 % of dentin), a calcium phosphate compound. This ingredient is safe and highly biocompatible. Nano medical hydroxyapatite (<mHAP>) particles penetrate below the surface of the enamel, providing replacement calcium and phosphate ions to areas from which minerals have dissolved, thereby remineralizing the demineralized enamel and restoring its integrity and translucent gloss.

작용기전

치아의 주성분은 하이드록시아파타이트(에나멜의 97%, 덴틴의 70%), 즉 칼슘포스페이트 컴파운드이다. 하이드록시아파타이트는 안전하며 매우 생체친화적인 물질이다. 나노 메디칼 하이드록시아파타이트(nano m<HAP>) 입자는 에나멜 하층으로 침트해 들어가 미네랄이 용해된 지역에 칼슘과 포스페이트이온을 공급하며 그 결과 탈회 된 지역을 재광화하며 치아 본연의 광택과 강도를 수복한다.

Remineralizes and repairs tooth surface

• Causes remineralization comparable to a fluoride toothpaste and inhibits caries development, thus suggesting that a nano medical hydroxyapatite toothpaste can be an effective alternative to fluoride toothpastes.¹
• Remineralizes subsurface demineralized areas of tooth enamel.²
• Remineralizes tooth enamel more effectively than saliva and just as effectively as fluoride compounds. Note : fluoride promotes remineralization by saliva, where as nano medical hydroxyapatite itself remineralizes the teeth.³
• Fills and repairs minute surface defects on tooth enamel, restoring enamel to its original smoothness.⁴
• Adheres to and helps remove bacteria and biofilm, thereby protecting against tooth decay.⁵
• Removes white spots and incipient caries and restores enamel almost to its original form.⁶
• Protects against biofilm attachment and stains by reducing the crevices that harbor them.⁷

^{치면의 수복과 재광화}

^{불소 치약과 비교하여 치아재광화 효과가 유사하다. 이는 나노 메디칼 하이드록시아파타이트 치약이 불소함유 치약의 대체재로 효과적임을 의미한다.}

^{탈회한 치아에나멜 하방의 재광화}

^{타액보다 효과적으로 치아에나멜을 재광화하고 불소화합물만큼 효과적이다. 불소는 타액에 의해 재광화를 촉진하는 반면 나노 하이드록시아파타이트는 그 자체로서 치아를 재광화한다.}

^{치아에나멜의 미세 표면 흠집을 메꾸고 수복하여 에나멜 원래의 매끈함을 회복시킨다.}

^{박테리아와 바이오필름의 부착을 어렵게하여 충치로부터 치아를 보호한다.}

^{치아의 흰색 반점과 초기우식을 제거하며 원래 형태의 에나멜을 수복한다.}

^{바이오필름과 착색물의 부착의 원인을 제공하는 미세한 흠집들을 제거함으로서  치아를 보호한다.}

Antimicrobial properties

• Absorbs periodontal and opportunistic pathogens such as p. gingivalis and candida, helping reduce the risk of oral soft tissue infection.⁸
• Shows superior bacterial absorption compared to other forms of hydroxyapatite.⁹
• Shows strong selectivity for cariogenic streptococcus mutans.¹⁰

항균효과

치주원인균을 흡수하여 구강연조직의 감염위험을 줄여준다.

어떤 다른 형태의 하이드록시아파타이트 보다 뛰어난 세균흡수율을 보여준다.

충치예방균을 선택적으로 제거하는데 강한 효과를 보인다.

Tooth sensitivity

Medical Hydroxyapatite nanoparticles occlude and offer a protective coating beyond comparison over exposed dentinal tubules, providing quick and effective relief from refractory tooth hypersensitivity.
Coats and fills exposed dentin and dentinal tubules protecting against dentinal hypersensitivity.¹¹

치아의 지각과민증상

메디칼 하이드록시아파타이느 나노입자는 노출된 상아세관을 봉쇄하는 보호막을 형성하여 빠르고 효과적으로 지각과민증상을 완화시킨다.

History of medical hydroxyapatite toothpastes

1970:
First synthetic form of hydroxyapatite created by NASA to help restore teeth and bone loss by astronauts following gravity-free environment missions.

1978:
Sangi Co., Ltd. acquires the patent from NASA and conceives the idea of an enamel-restorative toothpaste using the same substance as the tooth structure (hydroxyapatite).

1980:
Sangi launches the world’s first enamel-restorative toothpaste in Japan.

1985:
Studies from Tokyo Medical and Dental University (1 year / 1,026 children) and Asahi University (3 years / 181 children)
Results:
• Nano medical hydroxyapatite significantly lowered the incidence of new caries in previously and newly erupted teeth.
• In the 3-year study, the reduction was as high as 36 % to 56 %.

1993:
The Japanese government approves Sangi's proprietary medical hydroxyapatite as an active anti-caries agent.

2003:
Sangi increases the enamel-restorative capabilities of medical hydroxyapatite by reducing its nanoparticles from 100 to 50 nanometers (1 nanometer = 1 millionth of a millimeter), making it more effective at penetrating below the surface of the enamel.

2013:
• 100 million medical hydroxyapatite toothpastes sold by Sangi over the last 35 years.
• Nano medical hydroxyapatite is now the gold standard in Japan to fight cavities.

2015:
X-PUR Remin is granted the Health Canada indication of a fluoride free toothpaste that helps reduce caries.