ePTFE와 dPTFE의 단점을 극복한 마이크로포로스 PTFE, 비흡수성 테프가드

Cytoflex_clinical_study.pdf

Cytoflex TEF-GUARD에 관한 임상연구 파일입니다.

e-PTFE(Gore-Tex)와 d-PTFE(Cytoplast)의 단점을 극복하고 장점만 살린 비흡수성 차폐막

Cytoflex® PTFE TEF-GUARD Barrier Membrane

Historical Background
Guided tissue regeneration is a well established concept in the repair of oral bone defects. The exclusion of soft tissue epithelial and connective tissue cells from a bony defect, leading to enhanced bony repair is scientifically sound and has been proven clinically. Several types of membrane materials, including dense non-porous PTFE, porous expanded PTFE and certain resorbable membrane materials have been used in periodontal and oral surgery with success. Current evidence suggests that the physical blockade of cell migration is primarily responsible for the enhanced healing and regeneration.

Porous-ePTFE (P-ePTFE) and Non-Porous-PTFE (NP-ePTFE)
Many different membrane materials are currently available for clinical applications, including cellulose, collagen, polylactic acid, polyglycolic acid and lactide/glycolide copolymers and PTFE. Due to its superior biocompatibility and long history of use, the first generation, highly porous expanded PTFE membrane (P-ePTFE) has received the most attention in the literature. The large porosity of P-ePTFE allows tissue integration within the barrier membrane and minimizes early exposure due to sloughing off of thin flaps. However, P-ePTFE often results in the heavy accumulation of microorganisms within the interstices of the material when exposed to the oral environment. In addition, it is very difficult for surgeon to remove the highly tissue-integrated porous barrier membrane at the end of the guided tissue regeneration process.
Recently, a dense, non-porous PTFE membrane (NP-PTFE) has been proposed as a superior barrier membrane for alveolar ridge preservation and reconstruction. The smooth, non-porous PTFE membrane precludes the connective tissue and cells from migrating into the bony defect, prevents the accumulation of micro-organisms within the membrane and allows for easy removal of the membrane material after tissue regeneration. Nonetheless, the dense PTFE is stiffer and its smooth surface is difficult for cells and tissue to attach, often resulting in early flap sloughing off and exposure. As an improvement, NP-PTFE is embossed with micro texture to encourage tissue and cell attachment. NP-PTFE had been approved and is commercially available for clinical applications.

Micro-Porous-ePTFE (MP-ePTFE)
Unicare Biomedical, Inc. has developed “Cytoflex®”, a micro-porous ePTFE barrier membrane (MP-ePTFE), which exhibits the synergic advantages of both porous and non-porous PTFE membranes. The micro pores allow certain nutrients to pass through the barrier membrane, but block the ingrowths of connective tissue, cells and micro organisms. Micro- porosity also enhances the adhesion of host cells to MP-ePTFE membrane, while still permitting the barrier to be removed with ease after wound healing.

Cytoflex_clinical_study.pdf

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