하이드록시아파타이트 15%의 재광화 효과 : 불소 12,500ppm

불소는 충치예방효과가 있지만 독성물질입니다. 불소는 체내에 축척 되며 유아기의 뇌지능발달, 청소년기의 치아불소증, 노년기의 골격불소증의 원인이 됩니다.

 

하이드록시아파타이트는 치아와 같은 성분의 미네랄로 칼슘 과 인의 원료입니다. 삼켜도 인체에 무해합니다.

 

2020 Jul 22;6:9.

doi: 10.1038/s41405-020-0037-5. eCollection 2020.

 

Comparison of hydroxyapatite and fluoride oral care gels for remineralization of initial caries: a pH-cycling study

Bennett T Amaechi 1 , Parveez Ahamed AbdulAzees 1 , Linda O Okoye 2 , Frederic Meyer 3 , Joachim Enax 3

 

Abstract

Objective: The present in vitro study investigated if simulated daily use of hydroxyapatite-based gel (15% HAP) remineralizes early caries lesions as effective as weekly use of high fluoride (12,500 ppm) concentration gel, comparing them with artificial saliva alone.

Materials and methods: Three tooth blocks were produced from each of 20 bovine teeth. Caries-like lesion was created on each block by 4-day demineralization in acidified gel. The blocks were randomized into three remineralization groups (20 blocks/group); Hydroxyapatite-based gel (Karex gelée, 15% HAP, fluoride-free), fluoride-based gel (Elmex gelée, 12,500 ppm F-), and artificial saliva (AS). Remineralization was conducted using pH-cycling model for 28 days with storage in AS. The pH cycling model consisted of 2 h demineralization once daily for all groups, and 3 min HAP gel application once daily, 3 min fluoride gel application once weekly, or remain in AS only respectively. Baseline and post-test mineral loss were quantified using microradiography.

Results: Paired t-tests (baseline vs. post-Test) indicated significant (p < 0.0001) remineralization in all groups. When compared against each other using Games-Howell's multiple comparison test, no significant difference in remineralization was observed between the two gels, but both gels exhibited significantly (p < 0.001) higher percentage mineral gain (HAP:39 ± 7%; fluoride:41 ± 11%) than AS alone (6 ± 2%).

Conclusion: Hydroxyapatite-based gel (15% HAP) was as effective as fluoride-based gel (12,500 ppm F-) in remineralizing initial caries lesion.

Keywords: Minimal intervention dentistry; Oral hygiene.

 

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