Clinical efficacy of nano-hydroxyapatite in dentin hypersensitivity: A systematic review and meta-analysis.
Author information
- 1
- School of Dentistry, Federal University of Para, Belém, PA, Brazil.
- 2
- School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
- 3
- School of Dentistry, Federal University of Para, Belém, PA, Brazil. Electronic address: cecymsilva@gmail.com.
Abstract
OBJECTIVES:
To evaluate the desensitizing effect of nano-hydroxyapatite (n-HAP) on dentine hypersensitivity (DH).
SOURCES:
Seven electronic databases were searched on April 27, 2018.
STUDY SELECTION:
Randomized clinical trials (RCTs) were included based on the PICO strategy: Participants - Humans with DH; Intervention - n-HAP-containing desensitizing; Comparison -n-HAP-free treatments or placebo/negative control; and Outcomes - relief of DH. The risk of bias was classified by the Cochrane guidelines. Five meta-analyses were performed to evaluate the efficacy of n-HAP with regard to pain assessment stimuli (primary outcome); comparison of n-HAP with other treatments or placebo/negative control, and effectiveness of at-home and in-office n-HAP use (secondary outcomes). The quality of the evidence was evaluated using the GRADE.
DATA:
Six RCTs with 4 weeks of follow-up were included in the meta-analysis. For the primary outcome, n-HAP showed a better desensitizing effect for evaporative stimuli (SMD -1.09 [-1.24, -0.94], p < 0.00001) and tactile stimuli (SMD -0.93 [-1.42, -0.43]) than other treatments (p = 0.0002). However, there was no difference between n-HAP and other treatments for the cold stimuli (SMD -0.17 [-0.81, 0.48], p = 0.61). In an overall analysis, n-HAP-containing treatment showing the most significant desensitizing effect (SMD -0.93 [-1.19, -0.68], p < 0.00001) with a high quality of evidence for pooled results. In the secondary outcomes, n-HAP showed the best effect in the overall analysis (p < 0.05) with moderate quality evidence.
CONCLUSIONS:
The n-HAP-containing treatment showed better clinical performance than other treatments for DH relief. However, long-term follow-up RCTs are required in the future before definitive recommendations can be made.
결론: 나노하이드록시 아파타이트 함유 치료는 다른 방법보다 DH(치아지각과민)증상 완화에 더 뛰어난 임상결과를 보여주었다.
CLINICAL SIGNIFICANCE:
Dentin hypersensitivity is a common global condition and its multifactorial etiology has led to the development of several treatments. The n-HAP-containing treatment showed greater DH relief when compared to other desensitizing agents, placebo or negative control.
임상적인 의미: 상아질 지각과민(시린이)는 세계적으로 흔한 질환이다. 나노 하이드록시아파타이트 함유 처치가 기타 다른 지각과민처지재에 비해 월등한 효과를 보여 주었다.
위 마크는 일본 산기사의 나노입자 하이드록시아파타이트를 의미합니다.
나노입자로 조절되지 않고 상아세관 봉쇄 효과가 검증 되지 않은 하이드록시아파타이트는 치면연마재에 불과합니다.
거친 치면 연마재는 에나멜에 미세한 흠집을 남겨 에나멜을 손상시킬 수 있습니다.
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