나노 하이드록시아파타이트가 상아질지각과민(시린이)에 미치는 임상적 영향

연구 논문중 가장 신뢰성이 높은 것은 기존에 발표된 논문들을 쳬계적으로 분석해서 발표하는 논문입니다.

이를 Systemic Reviews and Meta-analyses라고 합니다.

상아질 지각과민을 쉬운 말로 하면 시린이입니다. 시린이의 원인은 법랑질 손상이나 치주질환으로 인해 상아질이 노출 되었을 경우 생깁니다. 시린이를 치료하는 방법은 이 노출된 상아세관을 코팅하고 봉쇄하는 것입니다.

J Dent. 2019 Mar;82:11-21. doi: 10.1016/j.jdent.2018.12.014. Epub 2019 Jan 3.

Clinical efficacy of nano-hydroxyapatite in dentin hypersensitivity: A systematic review and meta-analysis.

나노 하이드록시아파타이트가 상아질 지각과민에 미치는 임상적효과: 체계적 리뷰와 메타분석

de Melo Alencar C¹, de Paula BLF¹, Guanipa Ortiz MI¹, Baraúna Magno M², Martins Silva C³, Cople Maia L².

Author information

1

School of Dentistry, Federal University of Para, Belém, PA, Brazil.

2

School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

3

School of Dentistry, Federal University of Para, Belém, PA, Brazil. Electronic address: cecymsilva@gmail.com.

Abstract

OBJECTIVES:

To evaluate the desensitizing effect of nano-hydroxyapatite (n-HAP) on dentine hypersensitivity (DH).

SOURCES:

Seven electronic databases were searched on April 27, 2018.

STUDY SELECTION:

Randomized clinical trials (RCTs) were included based on the PICO strategy: Participants - Humans with DH; Intervention - n-HAP-containing desensitizing; Comparison -n-HAP-free treatments or placebo/negative control; and Outcomes - relief of DH. The risk of bias was classified by the Cochrane guidelines. Five meta-analyses were performed to evaluate the efficacy of n-HAP with regard to pain assessment stimuli (primary outcome); comparison of n-HAP with other treatments or placebo/negative control, and effectiveness of at-home and in-office n-HAP use (secondary outcomes). The quality of the evidence was evaluated using the GRADE.

DATA:

Six RCTs with 4 weeks of follow-up were included in the meta-analysis. For the primary outcome, n-HAP showed a better desensitizing effect for evaporative stimuli (SMD -1.09 [-1.24, -0.94], p < 0.00001) and tactile stimuli (SMD -0.93 [-1.42, -0.43]) than other treatments (p = 0.0002). However, there was no difference between n-HAP and other treatments for the cold stimuli (SMD -0.17 [-0.81, 0.48], p = 0.61). In an overall analysis, n-HAP-containing treatment showing the most significant desensitizing effect (SMD -0.93 [-1.19, -0.68], p < 0.00001) with a high quality of evidence for pooled results. In the secondary outcomes, n-HAP showed the best effect in the overall analysis (p < 0.05) with moderate quality evidence.

CONCLUSIONS:

The n-HAP-containing treatment showed better clinical performance than other treatments for DH relief. However, long-term follow-up RCTs are required in the future before definitive recommendations can be made.

CLINICAL SIGNIFICANCE:

Dentin hypersensitivity is a common global condition and its multifactorial etiology has led to the development of several treatments. The n-HAP-containing treatment showed greater DH relief when compared to other desensitizing agents, placebo or negative control.

대조군들에 비해서 나노 하이드록시아파타이트의 지각과민완화 효가가 월등히 뛰어나다.

Copyright © 2019 Elsevier Ltd. All rights reserved.

KEYWORDS:

Clinical trials; Dentin hypersensitivity; Desensitizing agents; Meta-analysis

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