Microb Pathog. 2018 Oct;123:177-182. doi: 10.1016/j.micpath.2018.06.038. Epub 2018 Jun 26.
Coupling xylitol with remineralizing agents improves tooth protection against demineralization but reduces antibiofilm effect.
치아재광화촉진제와 자일리톨 조합이 탈회예방과 바이오필름 감소에 도움
Gargouri W1, Zmantar T2, Kammoun R3, Kechaou N4, Ghoul-Mazgar S3.
Abstract
To explore the efficiency of xylitol chewing gum enriched or not with remineralizing agents to protect tooth against cariogenic biofilm formation and demineralization. Six groups of chewing gums were prepared; Group 1: isomalt (1.8%), Group 2: casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) (3%) + isomalt (1.8%), Group 3: hydroxyapatite (HAP) (2.5%) + isomalt (1.8%), Group 4: xylitol (1.8%), Group 5: CPP-ACP (3%) + xylitol (1.8%) and Group 6: HAP (2.5%) + xylitol (1.8%). The antibiofilm properties of different chewing gum extracts using seven oral bacterial species including Streptococcus mutans, Streptococcus constellatus, Streptococcus Salivarius and Streptococcus oralis were explored via the crystal violet staining assay. The remineralizing effects of those products were assessed on thirty human permanent teeth, half-protected with varnish before chemical erosion and thermocycling process with chewing gum. Remineralization was evaluated using scanning electron microscopy and microscopic measurements on polarized light microscopy. The ratio R comparing the thickness between unvarnished and varnished sides was evaluated. While the minimum biofilm inhibitory concentration (MBIC50) was low for xylitol alone compared to isomalt, it was inconsistent when enriched with remineralizing agents. The minimum biofilm eradication concentration (MBEC50) was low for xylitol groups compared to isomalt, for all the studied strains. R was significantly lower in Group 1 and Group 2, while Group 6 showed the highest ratio. Xylitol chewing gums confirmed good antibiofilm properties and showed remineralized potential on eroded teeth. When xylitol is associated to CPP-ACP or HAP, antibiofilm activity decreased while remineralization of eroded teeth increased.
자일리톨이 CPP-ACP나 HAP(하이드록시아파타이트)와 함께할때 바이오필름형성이 감소하고 부식된치아의 재광화효과가 증진된다.
자일리톨은 그 자체로서 치아를 재광화 촉진하는 효과가 있는 것이 아니라 구강내의 세균 활동을 억제해 치아에 칼슘과 인의 흡수를 돕습니다.
나노 하이드록시아파타이트는 그 자체로로 미네랄을 대체하는 치아재광화 촉진제로서 치아에 직접 흡수 되고 구강내의 미네랄의 균형을 유지합니다.
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